The Computational Biophysics Group (CBG) at UCI develops theoretical and computational methods to study complex biological systems. We focus on developing a molecular understanding of the essential machinery of life. Our research lies at the intersection of physics, biology, and chemistry, and is often carried out in close collaboration with leading experimentalists.

Recent Publications

The molecular mechanisms of visual chromophore release from cellular retinaldehyde-binding protein
Structure In Press (2025)
The molecular mechanisms of visual chromophore release from cellular retinaldehyde-binding protein
A conifer metabolite corrects episodic ataxia type 1 by voltage sensor mediated ligand activation of Kv1.1
Proceedings of the National Academy of Sciences, 122(2), e2411816122 (2025)
A conifer metabolite corrects episodic ataxia type 1 by voltage sensor mediated ligand activation of Kv1.1
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics
Structure 31 (7) 884-890.e2 (2023)
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics